Table 2.

SARS‐CoV‐2 proteins: Distinguishing features and significances

Region	Distinguishing feature	Significance
RdRp complex	N‐terminal β‐hairpin inserted into the groove clamped by the NiRAN and the palm subdomain	Stabilizes the polymerase structure
Spike protein	Furin cleavage site (RRAR) at the boundary of S1 and S2 subunits	Priming of the S protein increases the affinity for receptor
Furin cleavage site	The insertion of proline residue at the start of furin cleavage site	O‐linked glycosylation at S673, T678, and S686 resulting in strong shielding of SARS‐CoV‐2 epitopes
S1‐NTD	GTNGTKR motif	May assist to bind multiple receptors
N protein	NTD possesses distinguished surface charge distributions	Efficient binding between N protein and RNA genome

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