. 2021 Mar 11;93(5):3227–3237. doi: 10.1002/jmv.26902

Table 3.

The comparison of demographic and laboratory characteristics of confirmed COVID‐19 patients according to clinical classification of illness severity

	Univariate analysis			Multivariate analysis
Variables	nonsevere^a	severe^b	p Value	p Value	Odds ratio (95% confidence interval)
Patients, n (%)	231 (92)	20 (8)
Age, years, mean ± SD	7.57 ± 7.0	15.1 ± 2.1	.140
Gender, male, n (%)	131 (56.7)	8 (40)	.149
Laboratory findings
MPV (mean ± SD), fL	10.2 ± 0.9	10.3 ± 1.0	.060	.739	.890 (0.372–2.126)
PLT (mean ± SD)/mm³	281,750 ± 90,857	225,000 ± 80,876	.289
WBC (mean ± SD)/mm³	9490 ± 6368	13,073 ± 7502	.886
ANC (mean ± SD)/mm³	5046 ± 4697	11,550 ± 7687	.364
ALC (mean ± SD)/mm³	3277 ± 2407	726 ± 61	.098
Hb (mean ± SD), g/dl	12.6 ± 2.0	11.5 ± 2.4	.302
CRP (mean ± SD), mg/L	26.9 ± 50.8	78.2 ± 67.4	.004	.372	0.985 (0.954–1.018)
PCT (mean ± SD), µg/L	0.3 ± 0.8	3.5 ± 5.6	.068
D‐dimer (mean ± SD), µg/L	1251 ± 1169	2500 ± 2006	.068
Fibrinogen (mean ± SD), mg/dl	350 ± 119.3	444 ± 212.3	.004	.017	1.013 (1.002–1.023)
NT‐pro‐BNP (mean ± SD), ng/L	267.2 ± 367.9	73.4 ± 54.9	.130
NLR (mean ± SD)	2.6 ± 3.7	15.3 ± 9.3	.155
Lymphopenia n (%) (<1500/mm³)	56 (24.2)	9 (45)	.042	.031	7.562 (1.206–47.416)
Neutropenia, n (%) (<1500/mm³)	32 (13.9)	4 (20)	.452
Thrombocytopenia, n (%) (<150,000/mm³)	7 (3)	4 (20)	.000	.176	12.505 (0.324–483.398)

Note: The bold values indicate statistical analysis differences and correlations were considered significant at p < .05.

Abbreviations: ALC, absolute lymphocyte count; ANC, absolute neutrophil count; COVID‐19, coronavirus disease 2019; CRP, C‐reactive protein; Hb, Hemoglobin; MPV, mean platelet volume; NLR, neutrophil‐to‐lymphocyte ratio; NT‐pro‐BNP, N‐terminal‐pro‐brain natriuretic peptide; PCT, procalcitonin; PLT, platelet count; WBC, white blood cell.

^{^a}

Nonsevere: asymptomatic to mild.

^{^b}

Severe: moderate to critical.