. 2021 Feb 19;93(5):3143–3151. doi: 10.1002/jmv.26874

Table 1.

Amino acid residues that form hydrogen bonds between the three salvianolic acids and ACE2 or RBD

	ACE2	RBD
SAA	TYR83, GLU35, LYS31, HIS34^a	GLU406, GLN498,^a GLY496
SAB	ASN330, GLU329, ARG357,^a LYS353,^a ASP38, TYR41,^a GLN42^a	TYR453,^a GLN493, TYR449, TYR505, ASN501,^a THR500^a
SAC	ARG393, LYS353,^a LYS31	ARG403, GLU406, GLU484, PHE490

Abbreviations: ACE, angiotensin‐converting enzyme 2; RBD, receptor‐binding domain.

^{^a}

Amino residues are the active sites of ACE2 binding to RBD during virus invasion.