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. 2020 Dec 23;12:1758835920982853. doi: 10.1177/1758835920982853

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© The Author(s), 2020

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 5. — ATR and p-ATR expression in SKOV3 (A) and OVCAR8 (B) ovarian cancer cell lines was assessed by immunofluorescence with antibodies to ATR (green), p-ATR (green) and β-actin (red). Hoechst 33342 was added to counterstain the cell nucleus (blue). Green fluorescence of ATR resided within the cytoplasm and nucleus, whereas p-ATR protein was localized mainly in the nucleus alone. Expression of ATR, p-ATR, and cell proliferation were significantly reduced by ATR-specific siRNA treatment compared with non-specific siRNA treatment.

ATR, ataxia-telangiectasia and Rad3 related; DAPI, 4′,6-diamidino-2-phenylindole; p-ATR, phospho-ATR ser428.