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. 2020 Dec 23;12:1758835920982853. doi: 10.1177/1758835920982853

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© The Author(s), 2020

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 8. — Inhibition of ATR suppressed ovarian cancer cell clonogenicity and spheroid growth. (A) SKOV3 and OVCAR8 cell colony formation after treatment with VE-822 at different concentrations (0, 0.1, 0.5 µM) for 15 days. (B) Representative images of ovarian cancer cells after VE-822 treatment over different time points (3, 6, 9, 12 and 15 days). Original magnification, ×200. Scale bar 500 µm. (C) Spheroid diameters of SKOV3 and OVCAR8 cell lines cultured in 3D gels. p <0.001 compared with the untreated control group.

ATR, ataxia-telangiectasia and Rad3 related.