Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Mar 22;128(8):1388–1394. doi: 10.1111/1471-0528.16682

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2021 The Authors. BJOG: An International Journal of Obstetrics and Gynaecology published by John Wiley & Sons Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Placental pathology. (A) Transected placenta with confluent accumulation of fibrinoid demarcated (white broken line). (B,C) Massive intervillous fibrinoid deposition surrounding denuded villi with extravillous syncytiotrophoblasts (circles) located in the fibrinoid. (D) Acute intervillositis with karyorrhectic neutrophils in the intervillous space and degeneration of the villous trophoblast layer. (E) Representative region of chorangiosis. (F,G) Immunohistochemical staining for myeloperoxidase (MPO) and CD68 with positivity in inflammatory cells in areas of intervillositis. (H‐J) Severe acute respiratory syndrome coronavirus‐2 (SARSCoV‐2) nucleoprotein (NP) detected in nucleus and (circle in I) and cytoplasm in villous trophoblasts and syncytiotrophoblasts as well as in the nucleus of villous stromal cells (J) in areas of intervillositis. (K,L) Areas without intervillositis showed absent or focal staining for SARS‐CoV‐2 nucleoprotein of villi. (M) Double‐stranded RNA (dsRNA) detected in villous trophoblasts and syncytiotrophoblasts (circles).