Figure 1.

Outcomes of advanced lung cancer patients treated with ICI alone or in combination with chemotherapy. (A,B) PFS and OS in tumors treated with immunotherapy alone (n = 178) or in combination with chemotherapeutics (n = 147) [HR 0.430, 95% CI 0.319–0.579, log-rank p <1*10⁽⁻⁶⁾]. (C) Reasons for drug withdrawal in tumors from patients received immunotherapy or combination therapy. (D) Tumor burden scores of patients with progressive disease in different group (P = 0.284). (E,F) Metastases before our treatment (E) and recurrent or progressive sites after immunotherapy (F) were shown. Statistical analysis for Kaplan-Meier plots used the log-rank test and statistical analysis for progressive sites used Chi-square test; tumor burden score was tested by Independent samples t-test. PFS, progression-free survival; OS, overall survival; HR, hazard ratio; CI, confidence interval. ^aInformation on disease progression in two patients was not available.