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. 2021 Mar 18;11:611012. doi: 10.3389/fonc.2021.611012

Figure 4.

Figure 4

Time to onset irAEs and association with outcomes in advanced NSCLC patients treated with ICI monotherapy. (A,B) Kaplan-Meier curves of PFS (A) and OS (B) in patients with early (after 1–3 cycles), late (after four or more cycles) or without irAEs after commencement of ICI therapy. The multivariate HRs, 95% CIs and P-values were analyzed using a stratified Cox proportional hazards model taking into account gender (male, female), age (<65, ≥65), BMI (18) (<18.5, 18.5–22.9, 23–24.9, ≥25), smoking status (non-smoker, smoker), histology (adenocarcinoma, squamous carcinoma, NSCLC, neuroendocrine neoplasm, others), EGFR mutation (wild-type, mutation, unknown), PD-L1 expression level (<25%, ≥25%, unknown) and previous treatment lines (0, 1, ≥2). Log Rank p-values were calculated by log-rank test.