Table 3.
Correlation between clinical measurements and quantitative HRCT findings at baseline.
| Parameter, rho (p value) | % predicted FVC | % predicted DLCOa | UCSD-SOBQ total score |
|---|---|---|---|
| Predicted DLCOa, % | 0.2528 (p = 0.0029) | ||
| UCSD-SOBQ score | −0.0543 (p = 0.53) | −0.0385 (p = 0.65) | |
| QLF whole lung, % | −0.3656 (p < 0.0001) | −0.3816 (p < 0.0001) | 0.1049 (p = 0.29) |
| QILD whole lung, % | −0.3328 (p = 0.0001) | −0.2625 (p = 0.0019) | 0.09297 (p = 0.25) |
| QLF whole lung, ml | −0.2699 (p = 0.0014) | −0.3025 (p = 0.0003) | 0.0537 (p = 0.53) |
| QILD whole lung, ml | −0.1737 (p = 0.0423) | −0.1254 (p = 0.14) | 0.0583 (p = 0.50) |
a
QILD = QLF + QGG + QHC; QLF (ml) was derived from the product of CT TLC volume and QLF (%); Similarly, QILD (ml) was derived from the product of CT TLC volume and QILD (%).
DLCO, diffusing capacity of the lungs for carbon monoxide; FVC, forced vital capacity; HRCT, high-resolution computed tomography; QILD, quantitative interstitial lung disease; QLF, quantitative lung fibrosis; SD, standard deviation; TLC, total lung capacity; UCSD-SOBQ, University of California San Diego Shortness of Breath Questionnaire.