Table 4.
Correlation between change in clinical measurements and HRCT at week 26.
| Parameter, rho (p value) | Changes in % predicted FVC | Change in % predicted DLCOa | Change in UCSD-SOBQ total score |
|---|---|---|---|
| Changes in % predicted DLCOa | 0.3659 (p = 0.0001) | ||
| Changes in UCSD-SOBQ total score | −0.1772 (p = 0.0549) | −0.1217 (p = 0.19) | |
| Changes in QLF whole lung, % | −0.4142 (p < 0.0001) | −0.2166 (p = 0.0196) | 0.2680 (p = 0.0034) |
| Changes in QILD whole lung, %b | −0.3775 (p < 0.0001) | −0.2136 (p = 0.0213) | 0.1972 (p = 0.0323) |
| Changes in QLF whole lung, ml | −0.3540 (p = 0.0001) | −0.2022 (p = 0.0295) | 0.2723 (p = 0.0029) |
| Changes in QILD whole lung, mlb | −0.2700 (p = 0.0031) | −0.2069 (p = 0.0258) | 0.1491 (p = 0.1072) |
a
n = 116 for DLCO.
b
QILD = (QLF + QGG + QHC).
QLF (ml) was derived from the product of CT TLC volume and QLF (%); Similarly, QILD (mL) was derived from the product of CT TLC volume and QILD (%).
DLCO, diffusing capacity of the lungs for carbon monoxide; FVC, forced vital capacity; HRCT, high-resolution computed tomography; QILD, quantitative interstitial lung disease; QLF, quantitative lung fibrosis; UCSD-SOBQ, University of California San Diego Shortness of Breath Questionnaire.