Table 1.
Cohort Characteristics.
| Nontumorous Crooke’s Changes (+) | Nontumorous Crooke’s Changes’ (-) | |
|---|---|---|
| (N=50) | (N=10) | |
| Clinical Features | ||
| Age, average | 43±15 | 48±11 |
| Male, n (%) | 8 (16%) | 2 (20%) |
| Diabetes, n (%) | 20 (41%) | 2 (20%) |
| Hypertension, n (%) | 27 (55%) | 8 (80%) |
| Cardiomyopathy, n (%) | 3 (6%) | 0 (0%) |
| Skeletal Disease, n (%) | 9 (18%) | 2 (20%) |
| Imaging Features | ||
| Tumor Size | ||
| Microtumor, n (%) | 44 (88%) | 8 (80%) |
| Macrotumor, n (%) | 6 (12%) | 2 (20%) |
| Tumor Location* | ||
| Right Side, n (%) | 25 (50%) | 5 (50%) |
| Central, n (%) | 5 (10%) | 1 (10%) |
| Left Side, n (%) | 21 (42%) | 5 (50%) |
| Tumor Invasion** | ||
| Intrasellar, n (%) | 47 (94%) | 8 (80%) |
| Suprasellar, n (%) | 3 (6%) | 2 (20%) |
| Cavernous Sinus Invasion, n (%) | 3 (6%) | 2 (20%) |
*Pituitary tumor involving both right and left pituitary in two cases (one case with nontumorous CC+ and one case of CC-) and one case involving the right, left and central pituitary (in the group with no data regarding CC).
**Pituitary tumor involving invasion of both suprasellar structures and cavernous sinus in three cases.
The clinical features and imaging characteristics of patients with and without evidence of Crooke’s hyaline changes and patients with no data regarding Crooke’s hyaline changes.