Table 2.
Biochemical and Radiological Outcomes.
| Patients | Cortisol < 138 nmol/L within 7 days of surgery | Normal ACTH within 30 days of surgery | Normal MRI at the end of follow-up | Definition of Remission | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Yes | No | NA | Yes | No | NA | Yes | No | NA | Glucocorticoid Dependency | Normal 24-h UFC* | ||
| CC+, Remission | 36 | 26 (72%) | 6 (17%) | 4 (11%) | 23 (61%) | – | 13 (39%) | 28 (78%) | 4 (11%) | 4 (11%) | 9 (25%) | 27 (75%) |
| CC+, Persistence/Recurrence | 13 | 2 (15%) | 9 (69%) | 2 (15%) | 8 (62%) | 4 (31%) | 1 (8%) | 6 (46%) | 6 (46%) | 1 (8%) | – | – |
| CC-, Remission | 4 | 3 (75%) | 1 (25%) | – | 1 (25%) | – | 3 (75%) | 3 (75%) | – | 1 (25%) | 2 (33%) | 2 (33%) |
| CC-, Persistence/Recurrence | 5 | – | 5 (100%) | – | 4 (80%) | 0 (50%) | 1 (20%) | – | 5 (100%) | – | – | – |
*UFC, urinary free cortisol.
Remission or persistent/recurrent disease according to presence or absence of Crooke’s hyaline changes based on serum or urine cortisol levels, serum ACTH levels, imaging studies and glucocorticoid dependence.