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. 2021 Mar 18;11:574260. doi: 10.3389/fonc.2021.574260

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Copyright © 2021 Wu, Mao, Han, Wu and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PLAU1 overexpression promoted HNSCC cell proliferation, migration, invasion in vitro. (A) The expression levels of PLAU1, MMP1, MMP7, TIMP2, and CDH1 were detected by western blotting in HNSCC cells with PLAU1 overexpression. (B–E) The growth curve and colony-formation, invasion, and migration abilities of HNSCC cells with PLAU1 overexpression were detected using MTT assays (B), colony-formation assays (C), Transwell assays (D), and wound-healing assays (E), respectively. Data are presented as the mean ± SD from three independent experiments (**p < 0.01).