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. 2021 Mar 18;12:634365. doi: 10.3389/fphar.2021.634365

FIGURE 1.

FIGURE 1

Vild protects heart function and alleviates hyperglycemia-induced pathological changes. (A) M-mode echocardiograms and pulse-wave Doppler echocardiograms were used to examine cardiac function. Quantitative analysis of E/A (B), LVEF (C), LVFS (D), LVIDs (E), and LVIDd (F). Data are presented as mean ± standard deviation (SD). (G) Representative images of cardiac sections stained with HE, Masson, and immunohistochemically stained for Cx43. Scale bars in the right lower corner represent 20 μm. (H) Immunochemistry analysis of Cx43. (I) Representative western blotting (WB) images of Cx43. (J) Quantification of Cx43 protein levels. NC, normal control; DM, diabetic group; DM + vild, diabetic mice with vild administration; Cx43, connexin 43. Data are reported as mean ± standard error of mean (SEM). *p < 0.05.