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Von Hippel–Lindau (VHL)-based and cereblon (CRBN)-based small-molecule proteolysis-targeting chimeras (PROTACs). (A) Exemplified structures of VHL ligands and the PROTACs composed of them: VH032,24,26 VH101,25 VH298,25,26 MZ1,4 PROTAC_ RIPK2,27 PROTAC_ ERRα,27 ARD-266,137 VZ185,77 and ACBI1.138 (B) Exemplified structures of thalidomide and PROTACs composed of CRBN ligands: thalidomide,28 dBET1,3 dFKBP12,3 QCA570,139 PROTAC6,140 ZNL-02-096,141 and d9A-2.142
