Figure 4.
Inhibitor of apoptosis protein (IAP)-based and mouse double minute 2 homolog (MDM2)-based proteolysis-targeting chimeras (PROTACs), and von Hippel–Lindau (VHL)-based and cereblon (CRBN)-based homo-PROTACs. (A) Exemplified structures of methyl bestatin (MetBS) and Specific and Nongenetic Inhibitors of Apoptosis Protein (IAP)-Dependent Protein Eraser (SNIPERs): MetBS,37 SNIPER-2 (R = O)5 and SNIPER-4 (R = NH),38 SNIPER(ER)-87,39 SNIPER(BRD4)-1,40 and SNIPER(ABL)-62.41 (B) Structures of MDM2 inhibitors and PROTACs incorporating with them: nutlin,44 idasanutlin,46 PROTAC 14,45 A1874,148 Compound 3,149 and MD-224.47 (C) Structures of homo-PROTACs and related PROTACs composed with CRBN and VHL ligands: CM11,48 Compound 15a,49 CRBN-6-5-5-VHL,50 Compound 14a,51 and TD-165.52