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. 2021 Mar 18;12:601160. doi: 10.3389/fendo.2021.601160

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Copyright © 2021 Mueller, Kleemann, Gart, van Duyvenvoorde, Verschuren, Caspers, Menke, Krömmelbein, Salic, Burmeister, Seilheimer and Morrison

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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HC-24 treatment reduces neutrophil infiltration in Ldlr-/-.Leiden mice fed a translational HFD for 24 weeks. (A) Concentration of the neutrophil chemokine CXCL1 in liver tissue of chow, HFD + vehicle control and HFD + HC-24 groups. (B) Quantification of the immunohistochemical staining for the neutrophil marker GR-1, showing the number of GR-1-positive aggregates for each group. (C) Representative photomicrographs of immunohistochemical staining for the neutrophil marker GR-1 in cross sections of the medial lobe of the liver. Arrows indicate neutrophilic aggregates. (D) Quantification of the immunohistochemical staining for the macrophage marker F4/80, showing the number of F4/80-positive crown-like structures for each group. (E) Representative photomicrographs of immunohistochemical staining for the macrophage marker F4/80 in cross sections of the medial lobe of the liver. Arrows indicate F4/80-positive crown-like structures. HFD, high-fat diet; CLS, crown-like structure. Data shown are mean ± SD. *p < 0.05, ***p < 0.001 compared with HFD + vehicle.