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. 2021 Mar 18;12:601160. doi: 10.3389/fendo.2021.601160

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Copyright © 2021 Mueller, Kleemann, Gart, van Duyvenvoorde, Verschuren, Caspers, Menke, Krömmelbein, Salic, Burmeister, Seilheimer and Morrison

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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HC-24 treatment reduces free cholesterol accumulation in the liver of Ldlr-/-.Leiden mice fed a translational HFD for 24 weeks. (A) Hepatic triglyceride content. (B) Hepatic cholesteryl ester content. (C) Hepatic free cholesterol content. (D) Net whole-body cholesterol production in week 16 of the study. (E) Net whole-body cholesterol production in week 24 of the study. (F) Pearson correlation between free cholesterol in the liver and the histologically determined number of inflammatory aggregates in the liver. HFD, high-fat diet. Data shown are mean ± SD. *p < 0.05, **p < 0.01, ***p < 0.001 compared with HFD + vehicle.