Table 2. Median Time to Heal in Weeks by Treatment Group and Infantile Hemangioma Size.
| Variable | No. | Time to heal, median (95% CI), wk | P value |
|---|---|---|---|
| Treatment groupa | |||
| Wound care | 60 | 4.79 (3.71-5.86) | [Reference] |
| Multimodal | 64 | 7.71 (6.71-10.14) | <.001 |
| Pulsed-dye laser | 36 | 8.79 (8.00-11.29) | <.001 |
| Systemic β-blocker | 116 | 6.36 (5.57-8.00) | .002 |
| Timolol | 88 | 5.14 (4.57-6.00) | .21 |
| Size of hemangioma, cm2b | |||
| ≤5 | 135 | 5 (4.00-6.00) | [Reference] |
| >5 to ≤10 | 91 | 6.14 (5.71-8.00) | .02 |
| >10 to ≤50 | 113 | 8 (6.57-9.57) | <.001 |
| >50 to ≤100 | 14 | 9.29 (7.71-NA) | .004 |
| >100 | 11 | 7 (3.29-NA) | .74 |
Abbreviation: NA, not applicable (upper CI cannot be exactly estimated due to censoring of healing time values in the upper range).
a
The pairwise P value for treatment group multimodal vs pulsed-dye laser is P = .21; for multimodal vs systemic β-blocker, P = .47; for multimodal vs timolol, P = .03; for pulsed-dye laser vs systemic β-blocker, P = .07; for pulsed-dye laser vs timolol, P = .004; and for systemic β-blocker vs timolol, P = .07.
b
The pairwise P value for size of hemangioma >5 to ≤10 vs >10 to ≤50 is P = .19; for >5 to ≤10 vs >50 to ≤100, P = .04; for >5 to ≤10 vs >100, P = .29; for >10 to ≤50 vs >50 to ≤100, P = .14; for >10 to ≤50 vs >100, P = .13; and for >50 to ≤100 vs >100, P = .02.