Table 1. Screening, Subtyping, and Treatment Rates According to Patient Characteristics.
| Characteristic | Overall | Age, y | Sex | Hypokalemia | No. of antihypertensive drugsa | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| <40 | 40-59 | ≥60 | Male | Female | Present | Absent | <3 | ≥3 | ||
| Patients with hypertension | ||||||||||
| No. | 1 070 783 | 120 607 | 430 129 | 520 047 | 557 981 | 512 801 | 278 704 | 792 079 | 988 564 | 82 219 |
| % (95% CI) | NA | 11.3 (11.2-11.3) | 40.2 (40.1-40.3) | 48.6 (48.5-48.7) | 52.1 (52.0-52.2) | 47.9 (47.8-48.0) | 26.0 (25.9-26.1) | 74.0 (73.9-74.1) | 92.3 (92.3-92.4) | 7.7 (7.6-7.8) |
| Screening among those with hypertension | ||||||||||
| Patients screened | ||||||||||
| No. | 7941 | 2202 | 3181 | 2558 | 3770 | 4171 | 2818 | 5123 | 5949 | 1992 |
| % (95% CI) | 0.7 (0.7-0.8) | 1.8 (1.8-1.9) | 0.7 (0.7-0.8) | 0.5 (0.5-0.5) | 0.7 (0.7-0.7) | 0.8 (0.8-0.8) | 1.0 (1.0-1.1) | 0.7 (0.6-0.7) | 0.6 (0.6-0.6) | 2.4 (2.3-2.5) |
| Elevated ARR among those screened | ||||||||||
| No. | 1703 | 339 | 761 | 603 | 745 | 958 | 790 | 913 | 1129 | 574 |
| % (95% CI) | 21.4 (20.5-22.4) | 15.4 (13.9-17.0) | 23.9 (22.5-25.5) | 23.6 (21.9-25.3) | 19.8 (18.5-21.1) | 23.0 (21.7-24.3) | 28.0 (26.4-29.7) | 17.8 (16.8-18.9) | 19.0 (18.0-20.0.) | 28.8 (26.3-30.9) |
| Subtyping among those who had positive screening results | ||||||||||
| Received a CT or MRI of the abdomen | ||||||||||
| No. | 975 | 162 | 448 | 365 | 441 | 534 | 509 | 466 | 624 | 351 |
| % (95% CI) | 57.2 (54.9-59.6) | 47.8 (42.4-53.3) | 58.9 (55.3-62.4) | 60.5 (56.5-64.5) | 59.2 (55.6-62.7) | 55.7 (52.5-58.9) | 64.4 (61.0-67.8) | 51.0 (47.7-54.3) | 55.3 (52.3-58.2) | 61.2 (57.0-65.2) |
| Received adrenal vein sampling | ||||||||||
| No. | 250 | 56 | 146 | 48 | 135 | 115 | 141 | 109 | 156 | 94 |
| % (95% CI) | 14.7 (13.0-16.4) | 16.5 (12.7-20.9) | 19.2 (16.5-22.0) | 8.0 (5.9-10.4) | 18.1 (15.4-21.1) | 12.0 (10.0-14.2) | 17.9 (15.2-20.7) | 11.9 (9.9-14.2) | 13.8 (11.9-16.0) | 16.4 (13.4-19.7) |
| Received any subtyping | ||||||||||
| No. | 1005 | 175 | 460 | 370 | 452 | 553 | 521 | 484 | 642 | 363 |
| % (95% CI) | 59.0 (56.6-61.4) | 51.6 (46.2-57.1) | 60.5 (56.9-63.9) | 61.4 (57.3-65.3) | 60.7 (57.1-64.2) | 57.7 (54.5-60.9) | 66.0 (62.5-69.3) | 53.0 (49.7-56.3) | 56.9 (53.9-59.8) | 63.2 (59.2-67.2) |
| Targeted treatment among those who had positive screening results | ||||||||||
| Received a potassium-sparing diuretic | ||||||||||
| No. | 692 | 111 | 330 | 251 | 340 | 352 | 368 | 324 | 352 | 340 |
| % (95% CI) | 40.6 (38.3-43.0) | 32.7 (27.8-38.0) | 43.4 (39.8-47.0) | 41.6 (37.7-45.7) | 45.6 (42.0-49.3) | 36.7 (33.7-39.9) | 46.6 (43.1-50.1) | 35.5 (32.4-38.7) | 31.2 (28.5-34.0) | 59.2 (55.1-63.6) |
| Received an adrenalectomy | ||||||||||
| No. | 120 | 22 | 76 | 22 | 74 | 46 | 84 | 36 | 71 | 49 |
| % (95% CI) | 7.0 (5.9-8.4) | 6.5 (4.1-9.7) | 10.0 (7.9-12.3) | 3.6 (2.3-5.5) | 9.9 (7.9-12.3) | 4.8 (3.5-6.4) | 10.6 (8.6-13.0) | 3.9 (2.8-5.4) | 6.3 (4.9-7.9) | 8.5 (6.4-11.1) |
| Received any targeted treatment | ||||||||||
| No. | 731 | 118 | 356 | 257 | 363 | 368 | 389 | 342 | 385 | 346 |
| % (95% CI) | 42.9 (40.6-45.3) | 34.8 (29.7-40.1) | 46.8 (43.2-50.4) | 42.6 (38.6-46.7) | 48.7 (45.1-52.4) | 38.4 (35.3-41.6) | 49.2 (45.7-52.8) | 37.5 (34.3-40.7) | 34.1 (31.3-36.9) | 60.3 (56.1-64.3) |
Abbreviations: ARR, aldosterone-to-renin ratio; CT, computed tomography; MRI, magnetic resonance imaging; NA, not applicable.
a
Based on the number of drugs dispensed within 100 days of the index date.