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. 2021 Mar 10;60(18):10266–10272. doi: 10.1002/anie.202100225

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© 2021 Wiley‐VCH GmbH

This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response. It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency.

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Aptamer CoV2‐6 identification and characterization. A,B) Flow cytometry to monitor the binding increment of enriched pools with RBD‐Ni‐beads (target beads) and Ni‐beads (control beads). C) Flow cytometry to investigate the binding performance of candidate sequences against S_RBD. D) The results of molecular docking of overall structures of the CoV2‐6 aptamer (orange) and S_RBD complex (S_RBD is cyan and ACE2 binding amino acid residues are red), and E) the detailed analysis of the interface between CoV2‐6 aptamer and S_RBD. F) The ACE2 inhibition efficiency of candidate sequences. S_RBD was expressed by baculovirus‐insect cells.