Figure 4.

Characterization of the substrate‐binding site of 3CL^pro. (A) Expanded view of the substrate‐binding site of SARS‐CoV 3CL^pro in its inactive and active forms (PDB ID: 1UJ1 and 2AMQ). (B) Detailed configurations of all residues involved in the binding site. Conserved residues are highlighted in red. (C,D) Residue configurations of each subsite of SARS‐CoV‐2 3CL^pro (PDB ID: 6LU7). (E) The sequence logo69, 70 representation of the conservation of residues forming the binding site. The color coding is defined according to the chemical properties of amino acids (polar or neutral: black, basic: blue, acidic: red, and hydrophobic: orange) and the subsite legend is given under each amino acid [Color figure can be viewed at wileyonlinelibrary.com]