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A schematic representation of mode of action of 3CLpro inhibitors: (A) noncovalent, (B) irreversible covalent, and (C) reversible covalent inhibitors. The green triangle, orange sector, and red bold line represent the inhibitor, 3CLpro, and covalent bond, respectively. (D) Kinetics parameters for inhibitors binding with 3CLpro. (a k on : the ligand binding rate constant, b k off : the ligand disassociate rate constant) [Color figure can be viewed at wileyonlinelibrary.com]
