Table 1.

Selected potent 3CL^pro inhibitors (EC₅₀ characterizes the activity against virus cell, K _i and IC₅₀ respond to the activity against 3CL^pro)

		CoV type
Inhibitor type	Compound	SARS‐CoV	SARS‐CoV‐2	MERS‐CoV
Aldehyde	17	K i  = 0.053 μM
	26		EC50 = 2.07 μM
	28		IC50 = 0.053 μM
	29		IC50 = 0.040 μM
Aldehyde bisulfite adduct	49	IC50 = 0.030 μM		EC50 = 0.9 μM
	57	IC50 = 0.042 μM
Alpha‐ketoamide	68		EC50 = 0.49 μM
	70		IC50 = 0.045 μM
	71		IC50 = 0.012 μM
Benzotriazole	76	IC50 = 0.051 μM