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. 2021 Mar 15;13(3):1400–1410.

Figure 4.

Figure 4

mRNA expression of VEGF, ICAM-1 and E-Cadherin (A) after treatment with rHMGB-1 by dosage (48 h) and protein expression of VEGF (B). (A) VEGF mRNA expression was increased significantly according to the dose increase of rHMGB-1. ICAM-1 mRNA expression was increased only at 10 ng/mL of rHMGB-1, whereas E-Cadherin showed a significant decrease by rHMGB-1 treatment in a dose-dependent manner. (B) VEGF protein synthesis was significantly increased by rHMGB-1 treatment; however, there was no differences between rHMGB-1 treatment doses. *P < 0.05 compared to 0 ng/mL rHMGB-1 treatment.