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Cytokine secretion in ectopic HESCs after rHMGB-1 treatment. Secretion of pro-inflammatory cytokines including IL-6, TNF-α and IL-1β by ectopic HESCs was significantly increased with increased doses of rHMGB-1. Secretion of anti-inflammatory cytokine IL-6 was increased in a dose-dependent manner. *P < 0.05 compared to 0 ng/mL rHMGB-1 treatment.
