Figure 2.

Schematic representation of the IGFBP-1 protein. After dissociation of the signal peptide, the mature IGFBP-1 protein with 234 residues can be divided into three regions: the N-terminal region, the central linker region and the C-terminal region. IGFBP-1 contains five disulfide bond to provide a structural framework for IGF binding, and the domains of C-terminal region is described detailedly with one helix, six beta strand and one turn. The Ser-101, Ser-119 and Ser-169 in IGFBP-1 are the primary phosphorylation targets, and the RGD motif is located in residues 221 to 223.