Table 2.
Potential pathway of IGFBP-1 in multiple tumor types
| Tumor types | Potential pathway | Description | Refs |
|---|---|---|---|
| Liver Cancer | P38 MAPK/IGFBP-1/FOXO3a | Forming a feedback regulation loop with FOXO3a on p38 MAPK leading to an reciprocal pathway | [64] |
| HIF-2α/IGFBP-1/IGFs/IGF1R | Upregulated by HIF-2α to inhibit the actions of the IGFs/IGF1R system | [72] | |
| HBx/IGFBP-1/IGF-1/IGFR | Inhibited by HBx to enhanced IGF-1-dependent and -independent effects | [73] | |
| mTOR/CSNK-2β/IGFBP-1/IGF-1/IGF1R | Enhanced by CSNK-2β activation mediated by mTOR inhibition to decrease IGF-1-induced IGF1R autophosphorylation | [75] | |
| PXR/HNF4α | Derepressed by PXR via inhibiting the HNF4α gene | [77] | |
| Breast Cancer | α5/β1 integrin/FAK | Interacting with α5/β1 integrin and induce FAK dephosphorylation | [93] |
| α5/β1 integrin and IGF-1/IGF1R/IRS-2 | Interacting with α5/β1 integrin to enhance IRS-2 phosphorylation mediated by IGF-1/IGF1R | [61] | |
| GPER1/PKA/CREB/IGFBP-1/IGF1R/AKT, ERK1/2 | Facilitating phosphorylation of IGF1R, AKT and ERK1/2 in a GPER1/PKA/CREB-dependent pathway | [95] | |
| IGF1R/ERK1/2 or ERα/FoxO1 and CREB | Induced via the cooperation between CREB and FoxO1 mediated by IGF1R dependent ERK1/2 or ERα pathway | [96] | |
| Endometrial Cancer | FOXO1A and PGR | Enhanced by FOXO1A alone or with PGR in a co-operative way | [117] |
| Glioblastoma | P53/IGFBP-1/ERK1/2/ZIC2, NR2F1 | Enhanced by P53 and activating ERK1/2, ZIC2 and NR2F1 to form a self-activating pathway | [127] |
| SYK/PI3K/NFκB/MCSF | Induced by the SYK/PI3K/NFκB/MCSF mechanism and promotes angiogenesis | [128] | |
| Schwannoma | α5/β1 integrin/Src/FAK and PTEN/AKT | Interacting with α5/β1 integrin to stimulate Src/FAK signaling and inhibiting PTEN to increase AKT activity | [59] |