Figure 3.

Inhibition of STAT5 prevented the plaque development of atherosclerosis in HFD-fed ApoE^-/- mice. (A) Representative images of aortic arch showed that atherosclerotic lesion area was reduced by STAT5-IN-1. (B) Representative images of oil red O staining of en face showed that the atherosclerosis plaque was reduced by STAT5-IN-1. (C) Quantitative analysis of atherosclerotic plaque lesion area in the en face. (D-F) Representative images of oil red O staining in aortic root showed that the accumulation of lipid was reduced by STAT5-IN-1 (D) and quantitative analysis (E, F). (n=6 in each group; ***P < 0.001, vs. HFD).