FIGURE 3.

SARS‐CoV‐2 entry in normal physiological condition: (a) virus enter by membrane fusion, (b) through receptor‐dependent endocytosis, (c) through receptor‐independent endocytosis, (d) virus is uptake by host membrane‐bound vesicle where mACE2 is lost. When patient is non‐comorbid, virus can take its entry reducing surface ACE2; however, the Ang II‐mediated severity is thought to be moderate due to the high expression and regeneration of mACE2 and immune capacity of host. ACE2, angiotensin‐converting enzyme 2; Ang II, angiotensin II; mACE2, membrane ACE2; SARS‐CoV‐2, severe acute respiratory syndrome coronavirus 2