Table 2.
Results of univariate and multivariate analyses using Cox regression model
| Nonadjusted model HR, 95% CI, p value | Minimally adjusted model HR, 95% CI, p value | Fully adjusted model HR, 95% CI, p value | |
|---|---|---|---|
| Log2 bNC | 2.21 (1.20, 4.06) 0.0107 | 1.80 (0.95, 3.42) 0.0697 | 2.14 (1.12, 4.08) 0.0207 |
| Q1 | Ref | Ref | Ref |
| Q2 | 2.01 (0.18, 22.16) 0.5689 | 2.19 (0.19, 24.91) 0.5272 | 2.64 (0.23, 30.44) 0.4373 |
| Q3 | 3.04 (0.32, 29.26) 0.3354 | 2.30 (0.23, 22.59) 0.4741 | 3.44 (0.32, 36.78) 0.3072 |
| Q4 | 7.03 (0.85, 58.40) 0.0711 | 4.75 (0.57, 39.85) 0.1514 | 10.79 (1.10, 105.47) 0.0408 |
| p for trend | .0307 | .108 | .0234 |
| Log2 NCR1 | 0.77 (0.37, 1.60) 0.4773 | 0.77 (0.37, 1.60) 0.4808 | 0.70 (0.32, 1.53) 0.3764 |
| Q1 | Ref | Ref | Ref |
| Q2 | 1.31 (0.22, 7.83) 0.7696 | 1.38 (0.23, 8.31) 0.7226 | 1.33 (0.20, 8.64) 0.7684 |
| Q3 | 1.75 (0.32, 9.54) 0.5202 | 2.69 (0.47, 15.31) 0.2648 | 2.66 (0.41, 17.23) 0.3055 |
| Q4 | 0.33 (0.03, 3.67) 0.3688 | 0.32 (0.03, 3.66) 0.3615 | 0.27 (0.02, 3.37) 0.3077 |
| p for trend | .4754 | .5363 | .4445 |
| Log2 NCR2 | 1.23 (0.93, 1.63) 0.1408 | 1.27 (0.95, 1.69) 0.1082 | 1.25 (0.90, 1.73) 0.1810 |
| Q1 | Ref | Ref | Ref |
| Q2 | 1.70 (0.15, 18.81) 0.6658 | 2.86 (0.25, 33.18) 0.4016 | 1.93 (0.14, 26.17) 0.6215 |
| Q3 | 1.25 (0.28, 5.58) 0.7716 | 1.19 (0.26, 5.37) 0.8236 | 1.30 (0.24, 7.08) 0.7623 |
| Q4 | 3.13 (0.35, 28.11) 0.3077 | 4.63 (0.48, 44.30) 0.1835 | 4.88 (0.46, 52.05) 0.1898 |
| p for trend | .3412 | .2583 | .2146 |
Note: Nonadjusted model: no covariates were adjusted; Nonadjusted model: no covariates were adjusted; Fully adjusted model: all covariates presented in Table 1 were adjusted for.
Abbreviations: bNC, baseline neutrophil count; CI, confidence interval; HR, hazard ratio; NCR, neutrophil count change rate.