Table 1.

List of major PEGylated drugs approved by FDA in 2020 and their allergic effects

Active principle	Drug commercial name	Company	Therapic use	Examples of reports showing allergic and adverse effects
Recombinant anti‐hemophilic factor	Esperoct Turoctocog Aifa	Novo Nordisk Novoeight	Haemofilia A	Pires S et al.,. BMJ Case Rep. 2018 Dec 14;11(1):e227426.
G‐CSF	Ziextenzo (Pegfilmgrastim)	Sandoz	Treating neutropenia during chemotherapy	Bustillo I, et al., Cutan Ocul Toxicol. 2009;28(4):181‐4.
				Hanna GG, et al., Clin Oncol (R Coll Radiol). 2008 May;20(4):315‐6
Recombinant phenyl‐alanine ammonia lyase	Palynziq (Pegvaliase)	BioMarin Pharmaceuticals	Phenylketonuria	Zori R, et al., Mol Genet Metab. 2018 Nov;125(3):217‐227
l ‐Asparaginase	Aspartas	Servier Pharma	Leukemia	Fabry U et al., Pediatr Res. 1985 Apr;19(4):400‐8.
Recombinant coagulation factor IX	Rebinyn	Novo Nordisk	Hemophilia B	Levy‐Mendelovich S et al., Blood Cells Mol Dis. 2020 Feb;80:102370.
Recombinant anti‐hemophilic factor	Adinovate	Baxalta	Hemophilia A
PEGylated IFN‐α	Sylatron Peginterferon‐alpha‐2b	Merck	Melanoma	Meller S et al., Allergy. 2015 Jul;70(7):775‐83.
Anti‐TNF‐α	Cimzia (Cerulizumab‐pegol)	UCB	Rheumatoid arthritis	McCabe E et al., Rheumatology (Oxford). 2020 Apr 1;59(4):908‐910.
HGH (human growth hormne)	Somavert (Pegvisomant)	Pfizer	Acromegaly	Dadzie DD et al. Pituitary. 2012 Dec;15 Suppl 1:S68‐71

Abbreviations: G‐CSF, granulocyte colony‐stimulating factor; INF, interferon; TNF, tumor necrosis factor.