Table 1.

Peculiarity in the immune response in pediatric age with relevance in COVID‐19

Cellular adaptive immunity	Humoral adaptive immunity
↑ Thymic output	↑ Bone marrow output
↑ Repertoire of naive T‐cells	↑ Functional capacity of B‐cells
↑ Absolute values of CD4+ cells	Innate immunity and inflammation
↑ Absolute values of CD8+ cells	↑ Baseline tone of innate immunity
↑ Expression of CD27, CD28	↑Levels of mDC and pDC
	↓ Baseline pro‐inflammatory state

Abbreviations: COVID‐19, coronavirus disease 2019; mDC, myeloid dendritic cells; pDC, plasmacytoid dendritic cells.