Table 1.
Patient Case Summary With Triggering Agents and Associated PEG Compounds, Allergic Symptoms Experienced, Outcome of Skin Prick Testing, and Results of Supervised Provocation Challenges Detailed for Each Patient
| Case | Allergic Disease | Trigger | Symptoms | Negative Provocation Challenge | Positive Investigation |
|---|---|---|---|---|---|
|
Case 1 Female, 35 years |
None | Depo‐Provera: medroxyprogesterone PEG‐3350 |
Sneezing, ocular irritation, rhinorrhea, urticaria, hypotension, chest tightness, respiratory compromise. Biphasic urticaria. |
None |
SPT PEG‐3350: positive, 7 x 7 mm |
|
Case 2 Female, 25 years |
None |
Nexium: esomeprazole "Macrogols" MoviPrep: osmotic laxative PEG‐3350 Cosmetics: PEG‐100 |
Urticaria, angioedema, Respiratory compromise. Pruritus, urticaria, angioedema, hypotension, swelling of hands and feet. Biphasic urticaria. Contact urticaria. |
Celebrex: Celecoxib PEG‐free "Teva”: pantoprazole PEG‐free |
SPT PEG‐3350: positive, 10 x 11 mm |
|
Case 3 Female, 40 years |
None |
Effervescent vitamin C: HMW‐PEG Klean Prep: osmotic laxative PEG‐3350. Vimovo: esomeprazole, naproxen. PEG‐8000. EMLA topical anesthetic: lidocaine, prilocaine. HMW‐PEG. |
Urticaria, syncope. Urticaria, angioedema. Urticaria, presyncopal. Generalized pruritus. |
Cerazette: desogestrel PEG‐400 “Teva”: pantoprazole PEG‐free |
SPT PEG‐400, 3350: Inconclusive because of dermographism. Movicol challenge, PEG‐3350: positive |
|
Case 4 Female, 44 years |
None |
Klean Prep: osmotic laxative, PEG‐3350. Phosphate Sandoz: effervescent phosphate, PEG‐4000. Cosmetics: LMW‐ and HMW‐PEG. |
Perioral paresthesia, angioedema, dyspnea, stridor, visual disturbance, syncope. Angioedema, dyspnea, presyncope. Urticaria |
None |
SPT PEG‐3350: positive |
|
Case 5 Female, 36 years |
CSUA |
Motilium Suppository: domperidone, PEG‐400 and 1000. Nurofen: ibuprofen, PEG‐6000. |
Angioedema, paresthesia, throat tightness. Angioedema, paresthesia, throat tightness. |
Motilium oral tablet: PEG‐free Nurofen syrup: PEG‐free |
SPT PEG‐3350: positive |
|
Case 6 Female, 38 years |
CSUA Physical urticaria |
Betadine: wound dressing, povidone‐iodine, PEG‐400, 6000. Voltorol Oral: diclofenac PEG‐8000. Diclofenac IM: HMW‐PEG. Shaving foam: LMW‐ and HMW‐PEG. Cosmetics: LMW‐ and HMW‐PEG. |
Urticaria, presyncopal. Urticaria. Urticaria. Urticaria, angioedema, respiratory distress, hypotension. Contact urticaria. |
Celebrex: Celecoxib PEG‐free. Ibuprofen tablet: PEG‐free |
SPT PEG‐3350: 10 × 10 mm |