TABLE 3.
Correlations between lymphocytes subsets and cytokines
| Cytokines Lymphocyte subsets | IL‐17 A | IFNγ | TNFα | IL‐10 | IL‐6 | IL‐4 | IL‐2 |
|---|---|---|---|---|---|---|---|
| Lymphocytes | 0.058 | −0.162 | 0.271* | −0.455** | −0.554** | 0.295* | 0.123 |
| T cells (CD3+) | 0.030 | −0.229* | 0.290* | −0.465** | −0.547** | 0.296* | 0.107 |
| B cells (CD3−CD19+) | 0.102 | −0.158 | 0.221* | −0.463** | −0.501** | 0.111 | 0.117 |
| Natural killer (NK) cells (CD3−CD16+CD56+) | 0.154 | ,009 | 0.308** | −0.323** | −0.442** | 0.340** | 0.109 |
| CD4+ T cells | 0.082 | −0.221* | 0.316** | −0.482** | −0.537** | 0.295* | 0.110 |
| CD8+ T cells | −0.015 | −0.162 | 0.237* | −0.370** | −0.469** | 0.237* | 0.056 |
| DP T cells (CD3+CD4+CD8+) | −0.216 | −0.193 | 0.067 | −0.344** | −0.473** | 0.286* | 0.048 |
| CD4+CD45RA+ T cells | 0.174 | 0.016 | 0.031 | −0.124 | −0.061 | 0.108 | −0.117 |
| CD4+CD45RO+ T cells | −0.174 | −0.016 | −0.031 | 0.124 | 0.061 | −0.108 | 0.117 |
| RTEs (CD3+CD4+CD45RA+CD31+) | 0.212 | −0.052 | 0.096 | −0.251* | −0.187 | 0.207 | 0.041 |
| Naive CD8+ T cells (CD8+CD45RA+CCR7+) | 0.036 | −0.283* | 0.258* | −0.468** | −0.415** | 0.297* | 0.249* |
| TEMRA CD8+ T cells (CD8+CD45RA+CCR7−) | 0.063 | 0.351** | −0.071 | 0.364** | 0.234* | −0.199 | −0.258* |
| CM CD8+ T cells (CD8+CD45RA−CCR7+) | −0.164 | −0.274* | 0.085 | −0.205 | −0.097 | 0.299* | 0.154 |
| EM CD8+ T cells (CD8+CD45RA−CCR7−) | 0.000 | −0.084 | −0.152 | 0.036 | 0.114 | −0.090 | −0.024 |
| Activated CD4+ T cells (CD4+HLADR+CD38+) | −0.034 | 0.084 | −0.197 | 0.210 | 0.284* | −0.298* | −0.051 |
| Activated CD8+ T cells (CD8+HLADR+CD38+) | 0.007 | −0.148 | −0.076 | 0.113 | 0.266* | −0.144 | −0.038 |
The correlations were analyzed by the Spearman test. Data expressed as correlation coefficient.
* P < 0.05; ** P < 0.01. DP: double positive; RTEs: recent thymic emigrants; TEMRA: terminally differentiated effector memory‐RA; CM: central memory; and EM: effector memory.