Figure 1.

Structures of O and PD conformations of CD44 HABD. (a) X-ray structure (PDB ID: 1UUH) of the O conformation and (b) structure (PDB ID: 2I83) assigned by NMR analysis of the PD conformation.⁴ (c) PD refold conformation at 500 ns of MD simulation. The red dashed circles denote the partially disordered region on the conformational shift from O to PD, and the blue dashed circles denote the conformational change at the remote region during the conformational shift from O to PD and the refolding of PD conformation. The figures of (a) and (b) were reprinted with permission from ref (4). Copyright 2006 Elsevier.