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. 2021 Mar 23;21(5):540. doi: 10.3892/etm.2021.9972

Figure 2.

Figure 2

The mTOR signalling pathway: Structure, biological effects, and inhibitors [adapted from Saxton and Sabatini (2017) and Laplante and Sabatin (2012) (47,48)]. mTOR, mammalian target of rapamycin; DEPTOR, DEP-domain containing mTOR-interacting protein; PRAS40, proline-rich AKT substrate 40-kDa; mLST8, lethal mammalian with sec-13 protein 8; Raptor, regulatory-associated protein of TOR; Rictor, rapamycin insensitive companion of mTOR; mSIN1, stress-activated protein kinase-interacting protein 1.