Table IV.
Reactome pathway analysis of differentially expressed proteins between Baseline and VAP positive
| Pathway | Significant Proteins (p < 0.05) | p Value |
|---|---|---|
| Up Regulated | ||
| Neutrophil degranulation | FCN1;GGH;RETN;CFP;OLFM4;MPO;MMP9;NME1;CHIT1PNP;S100A9;S100A8;VCL | 6.59E-14 |
| Innate immune system | FCN1;CRP;GGH;RETN;CFP;OLFM4;MPO;MMP9;NME1CHIT1;PNP;MYH9;S100A9;S100A8;VCL | 6.24E-10 |
| Initial triggering of complement | FCN1;CRP;CFP | 9.27E-05 |
| Smooth muscle contraction | VCL;MYL12B | 6.68E-05 |
| EPH-Ephrin signaling | MYH9;MMP9;MYL12B | 5.55E-05 |
| RHO GTPases activate ROCKs, CIT, PAKS | MYH9;MYL12B | 9.89E-04 |
| Interconversion of nucleotide di- and triphosphates | AK2;NME1 | 6.07E-04 |
| Metal sequestration by antimicrobial proteins | S100A9;S100A8 | 3.20E-04 |
| Ficolins bind to repetitive carbohydrate structures on the target cell surface | FCN1 | 2.73E-04 |
| Metabolism of nucleotides | PNP;AK2;NME1 | 1.60E-03 |
| Downregulated | ||
| Erythrocytes take up oxygen and release carbon dioxide | CA1;CA2; HBA1;HBA2;HBB | 4.33E-07 |
| Neutrophil degranulation | CD59;PRDX6;LGALS3;XRCC5;CFD;TTR;HSG;GSN;B2M;ALDH2B1;HBB;STOM;CTSD;CTSH | 9.58E-06 |
| Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | YWHAB;YWHAH;YWHAZ | 1.02E-04 |
| Detoxification of reactive oxygen species | PRDX1;PRDX2;PRDX6;SOD3 | 2.06E-04 |
| TP53 regulates metabolic genes | PRDX1;PRDX2;YWHAB;YWHAZ;YWHAH | 4.92E-04 |
| Neurodegenerative diseases | PRDX1;PRDX2;LMNA | 6.77E-04 |
| Scavenging of heme from plasma | HBA1;HBA2;JCHAIN;KappaChainVII-SIE, KappaChainC | 8.32E-04 |
| Amyloid fiber formation | TTR;GSN;B2M;APOA4 | 1.80E-03 |
| Platelet degranulation | LGALS3BP;CFL1;CFD;AHSG;CLEC3B | 2.55E-03 |