Table 3.
Associations between genotypes of acrylamide-metabolising enzymes and birth outcomes
| SNPa | Estimated change in birth outcome (95% CI) | |||||
|---|---|---|---|---|---|---|
| Birth weight (gram) | p | Birth length (cm) | p | Birth head circumference (CM) | p | |
| rs915906 | 24.5 (−36.9, 86.0) | 0.43 | −0.17 (− 0.44, 0.10) | 0.22 | − 0.04 (− 0.26, 0.19) | 0.74 |
| rs2480258 | 19.1 (−40.3, 78.5) | 0.53 | − 0.19 (− 0.45, 0.07) | 0.16 | − 0.02 (− 0.24, 0.20) | 0.85 |
| rs11101888 | 18.8 (− 56.0, 93.7) | 0.62 | 0.05 (− 0.28, 0.38) | 0.77 | 0.19 (− 0.07, 0.44) | 0.15 |
| rs1051740 | −17.6 (−76.3, 41.1) | 0.56 | 0.05 (− 0.21, 0.31) | 0.70 | − 0.02 (− 0.23, 0.20) | 0.89 |
| rs1695 | 2.0 (−56.2, 60.2) | 0.95 | −0.02 (− 0.28, 0.23) | 0.86 | 0.04 (− 0.17, 0.25) | 0.71 |
| rs1138272 | −7.3 (−86.6, 72.1) | 0.86 | −0.09 (− 0.44, 0.26) | 0.60 | − 0.03 (− 0.32, 0.27) | 0.86 |
Adjusted for: maternal pre-pregnancy BMI (kg/m2), maternal weight gain during pregnancy, maternal smoking during pregnancy (n cigarettes/day), parity (n children), gestational age (weeks), newborn’s sex and date of delivery
amodeled is the regression coefficient of 1 or 2 variant alleles of the SNP compared to the homozygous wildtype