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. 2021 Apr 1;20:35. doi: 10.1186/s12940-021-00715-0

Table 4.

Associations between acrylamide and glycidamide hemoglobin adducts in cord blood and birth outcomes

Unadjusted regression coefficient (95% CI) Multivariable-adjusted regression coefficient (95% CI)
Continuous exposure variable (per 10 pmol/g hemoglobin) Quartiles of exposure Continuous exposure variable (per 10 pmol/g hemoglobin) Quartiles of exposure
n Regression coefficient (95% CI)a p Q1
REF		 Q2 Q3 Q4 p for trend Regression coefficient (95% CI)a p Q1
REF		 Q2 Q3 Q4 p for trend
Acrylamide hemoglobin adducts among all participants
 Weight, g 443

−59

(−88, −31)

 < 0.001 1

−74

(−188, 41)

−98

(− 212, 17)

− 149

(− 263, 34)

 0.08

−40

(− 71, −9)

 0.01 1

−30

(− 127, 67)

−102

(−200, − 5)

−101

(−208, 7)

 0.12
 Length, cm 442

−0.24

(−0.37, − 0.11)

 < 0.001 1

− 0.22

(− 0.73, 0.30)

0.17

(− 0.35, 0.68)

−0.35

(− 0.86, 0.16)

 0.19

−0.17

(− 0.31, − 0.03)

 0.02 1

−0.03

(− 0.48, 0.41)

0.15

(−-0.29, 0.60)

−0.13

(− 0.62, 0.36)

 0.69
 Head circumference, cm 432

−0.15

(− 0.24, − 0.05)

 0.003 1

−0.33

(− 0.72, 0.06)

−0.51

(− 0.90, − 0.12)

−0.54

(− 0.92, − 0.15)

 0.03

−0.13

(− 0.24, − 0.01)

 0.03 1

−0.16

(− 0.52, 0.19)

−0.45

(− 0.81, − 0.09)

−0.41

(− 0.80, − 0.01)

 0.06
Acrylamide hemoglobin adducts among neonates from non-smoking mothers
 Weight, g 380

−58

(−113, − 4)

 0.04 1

−67

(− 181, 47)

− 88

(− 202, 25)

− 30

(− 170, 110)

 0.45

−52

(− 98, − 5)

 0.03 1

−26

(− 123, 72)

− 101

(− 200, − 2)

− 77

(− 197, 43)

 0.19
 Length, cm 379

−0.17

(− 0.42, 0.08)

 0.18 1

− 0.21

(− 0.73, 0.31)

0.19

(− 0.33, 0.70)

0.27

(− 0.37, 0.90)

 0.35

−0.18

(− 0.40, 0.04)

 0.10 1

− 0.04

(− 0.49, 0.41)

0.15

(− 0.31, 0.60)

−0.00

(− 0.56, 0.55)

 0.86
 Head circumference, cm 369

−0.23

(− 0.42, − 0.04)

 0.02 1

−0.32

(− 0.72, 0.07)

−0.48

(− 0.87, − 0.08)

−0.36

(− 0.85, 0.13)

 0.12

−0.22

(− 0.40, − 0.05)

 0.01 1

−0.16

(− 0.52, 0.21)

−0.42

(− 0.80, − 0.05)

−0.48

(− 0.94, − 0.03)

 0.07
Glycidamide hemoglobin adducts among all participants
 Weight, g 393

−80

(− 117, − 44)

 < 0.001 1

− 161

(− 282, − 40)

− 175

(− 297, − 54)

−267

(− 387, − 146)

 < 0.001

− 53

(− 90, − 16)

 0.005 1

− 144

(− 246, − 43)

− 154

(− 258, − 49)

−222

(− 337, − 108)

 0.001
 Length, cm 392

− 0.35

(− 0.52, − 0.19)

 < 0.001 1

−0.55

(− 1.09, − 0.01)

− 0.59

(− 1.13, − 0.05)

−1.10

(− 1.64, − 0.56)

 0.001

− 0.24

(− 0.41, − 0.08)

 1

−0.46

(− 0.93, 0.01)

−0.48

(− 0.96, − 0.00)

−0.85

(− 1.38, − 0.33)

 0.02
 Head circumference, cm 382

− 0.17

(− 0.30, − 0.05)

 0.007 1

− 0.69

(− 1.10, − 0.27)

− 0.74

(− 1.16, − 0.33)

− 0.74

(− 1.15, − 0.32)

 < 0.001

− 0.11

(− 0.25, 0.03)

 1

− 0.61

(− 0.99, − 0.23)

− 0.61

(− 1.00, − 0.21)

− 0.55

(− 0.98, − 0.11)

 0.01
Glycidamide hemoglobin adducts among neonates from non-smoking mothers
 Weight, g 331

−121

(− 193, − 50)

 < 0.001 1

− 164

(− 285, − 43)

− 176

(− 296, − 50)

−176

(− 327, − 25)

 0.01

− 104

(− 165, − 43)

 0.001 1

−152

(− 255, − 50)

−161

(− 268, − 54)

−225

(− 355, − 95)

 0.002
 Length, cm 330

− 0.48

(− 0.80, − 0.15)

 0.004 1

−0.56

(− 1.11, − 0.01)

−0.61

(− 1.17, − 0.05)

−0.64

(− 1.33, 0.05)

 0.10

− 0.42

(− 0.70, − 0.13)

 0.004 1

−0.50

(− 0.98, − 0.02)

− 0.56

(− 1.06, − 0.06)

−0.81

(− 1.42, − 0.21)

 0.04
 Head circumference, cm 320

− 0.36

(− 0.62, − 0.11)

 0.005 1

−0.69

(− 1.11, − 0.27)

−0.72

(− 1.15, − 0.29)

−0.55

(− 1.09, − 0.02)

 0.003

− 0.31

(− 0.55, − 0.07)

 0.01 1

−0.61

(− 1.01, − 0.22)

−0.61

(− 1.02, − 0.19)

−0.63

(− 1.14, − 0.13)

 0.007

Adjusted for: maternal pre-pregnancy BMI (kg/m2), maternal weight gain during pregnancy, maternal smoking during pregnancy (n cigarettes/day), parity (n children), gestational age (weeks), newborn’s sex and date of delivery

aRegression coefficient (95% confidence interval) per 10 pmol/g hemoglobin increase in AA-Hb and GA-Hb adducts