Table 6.

Associations between SNPs in acrylamide-metabolising genes and the ratio of glycidamide to acrylamide hemoglobin adducts

SNP ID	n	Homozygous wildtype	n	Heterozygous	p	n	Homozygous variant allele	p
		Regression coefficient (95% CI)		Regression coefficient (95% CI)			Regression coefficient (95% CI)
All
rs915906, CYP2E1	196	Ref	78	0.004 (−0.07, 0.08)	0.91	6	−0.12 (− 0.37, 0.14)	0.37
rs2480258, CYP2E1	174	Ref	99	0.04 (−0.03, 0.10)	0.30	9	−0.06 (− 0.26, 0.14)	0.56
rs11101888, CYP2E1	234	Ref	47	−0.04 (− 0.13, 0.05)	0.35	1	0.83 (0.34, 1.32)	0.001
rs1051740, EPHX1	157	Ref	107	−0.05 (− 0.12, 0.01)	0.10	25	−0.05 (− 0.16, 0.06)	0.36
rs1695, GSTP1	125	Ref	140	−0.04 (− 0.11, 0.02)	0.19	26	0.01 (−0.12, 0.13)	0.93
rs1138272, GSTP1	234	Ref	50	−0.01 (− 0.10, 0.07)	0.77	2	0.20 (−0.15, 0.55)	0.27
Non-smokers
rs915906, CYP2E1	169	Ref	64	0.03 (−0.06, 0.11)	0.56	6	−0.11 (− 0.38, 0.16)	0.43
rs2480258, CYP2E1	148	Ref	84	0.05 (−0.03, 0.12)	0.21	8	−0.11 (− 0.34, 0.13)	0.38
rs11101888, CYP2E1	199	Ref	40	−0.04 (− 0.14, 0.07)	0.48	1	0.84 (0.32, 1.36)	0.002
rs1051740, EPHX1	137	Ref	87	−0.07 (− 0.14, 0.01)	0.08	22	−0.05 (− 0.17, 0.07)	0.39
rs1695, GSTP1	105	Ref	121	−0.05 (− 0.12, 0.03)	0.20	23	0.02 (−0.12, 0.16)	0.76
rs1138272, GSTP1	202	Ref	41	−0.02 (− 0.12, 0.08)	0.69	2	0.14 (−0.16, 0.44)	0.36

Adjusted for: maternal pre-pregnancy BMI (kg/m²), maternal weight gain during pregnancy, maternal smoking during pregnancy (n cigarettes/day), parity (n children), gestational age (weeks), newborn’s sex and date of delivery