Table 3.
Demographic and clinical characteristics in PAH with (PAH-C) and without (PAH-D) hemodynamic compensation
| Variables | PAH-C (n = 55) |
PAH-D (n = 20) |
P value |
|---|---|---|---|
| Age, years | 36 ± 15 | 41 ± 14 | 0.246 |
| Gender, Male/Female | 9/46 | 7/13 | 0.081 |
| Body surface area, m2 | 1.5 ± 0.2 | 1.6 ± 0.3 | 0.074 |
| Diastolic blood pressure, mmHg | 69 ± 11 | 76 ± 15 | 0.026 |
| Systolic blood pressure, mmHg | 109 ± 17 | 118 ± 24 | 0.074 |
| Heart rate, bpm | 85 ± 16 | 87 ± 16 | 0.671 |
| WHO class (> 1), n (%) | 50 (91 %) | 19 (95 %) | 0.635 |
| 6MWD, m | 433 ± 86 | 380 ± 107 | 0.049 |
| Right heart catheterization | |||
| RA pressure, mmHg | 5 ± 2 | 16 ± 6 | < 0.001 |
| mPAP, mmHg | 53 ± 22 | 62 ± 22 | 0.137 |
| PCWP, mmHg | 9 ± 4 | 13 ± 4 | < 0.001 |
| PVR, Wood units | 11 ± 8 | 15 ± 11 | 0.146 |
| CMR: right ventricle | |||
| RVEDVI, ml/m2 | 120 ± 56 | 129 ± 68 | 0.584 |
| RVESVI, ml/m2 | 72 ± 44 | 81 ± 50 | 0.444 |
| RVSVI, ml/m2 | 48 ± 23 | 48 ± 26 | 0.910 |
| RVEF, % | 43 ± 13 | 40 ± 15 | 0.339 |
Data are presented as mean ± SD or n (%)
6MWD six-minute walking distance, CMR cardiovascular magnetic resonance, EDVI end-diastolic volume index, EF ejection fraction, ESVI end-systolic volume index, mPAP mean pulmonary artery pressure, PAH-C compensated pulmonary arterial hypertension, PAH-D decompensated pulmonary arterial hypertension, PCWP pulmonary capillary wedge pressure, PVR pulmonary vascular resistance, RA right atrial, RV right ventricular, SVI stroke volume index, WHO World Health Organization