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. 2021 Mar 16;6(12):8346–8355. doi: 10.1021/acsomega.1c00061

Table 4. Screening of Solvents for the Synthesis of N-Benzylated Isatoic Anhydrides for Scheme 3iii.

entry solvent time (h) yield (%)
5A1 DCM 24 85
5A2 benzene 4 95
5A3 chloroform 5 85
5A4 ethanol 6 55
5A5 ethyl acetate 6 50
5A6 AcCN 12 trace
5A7 THF 12 nil