Table 2.
Regions in the TBSS skeleton, containing significant voxels (Diagnosis X ID/ED Simple Reversal Error rate interaction): Linear regression results (B: slope of the regression and StdE: standard error for B). (White Matter region list restricted to significant regions with FDR p-value<0.05)
| White Matter Region | Voxel Number | TDC (n = 26) | BD (n = 28) | Between-Group Slope | Difference | ||
|---|---|---|---|---|---|---|---|
| B | StdE (B) | B | StdE (B) | FDR | |||
| F-value | p-value | ||||||
| Middle cerebellar peduncle (MCP) | 73 | −0.032 | 0.008 | 0.008 | 0.008 | 10.4 | 0.003 |
| Pontine crossing tract (PCT) | 96 | −0.022 | 0.006 | 0.009 | 0.005 | 14.5 | 0.001 |
| Genu of corpus callosum (GCC) | 818 | −0.02 | 0.005 | 0.01 | 0.003 | 25.6 | <0.001 |
| Body of the Corpus Callosum (BBC) | 1281 | −0.023 | 0.006 | 0.009 | 0.004 | 19.3 | <0.001 |
| Splenium of corpus callosum (SCC) | 1045 | −0.02 | 0.005 | 0.007 | 0.003 | 19.8 | <0.001 |
| Corticospinal tract R (CST_R) | 1 | −0.042 | 0.018 | 0.009 | 0.01 | 6.8 | 0.014 |
| Corticospinal tract L (CST_L) | 114 | −0.031 | 0.006 | 0.004 | 0.005 | 17.9 | <0.001 |
| Medial lemniscus L (ML_L) | 21 | −0.02 | 0.009 | 0.009 | 0.006 | 7.1 | 0.012 |
| Superior cerebellar peduncle L (SCP_L) | 42 | −0.021 | 0.006 | 0.005 | 0.005 | 9.7 | 0.004 |
| Cerebral peduncle R (CP_R) | 228 | −0.025 | 0.006 | 0.005 | 0.004 | 16.1 | <0.001 |
| Cerebral peduncle L (CP_L) | 146 | −0.019 | 0.006 | 0.008 | 0.004 | 12.4 | 0.001 |
| Posterior limb of internal capsule R (PLIC_R) | 195 | −0.017 | 0.004 | 0.005 | 0.003 | 19.8 | <0.001 |
| Posterior limb of internal capsule L (PLIC_L) | 102 | −0.019 | 0.005 | 0.006 | 0.003 | 15.4 | <0.001 |
| Retrolenticular part of internal capsule R (RPIC_R) | 251 | −0.02 | 0.005 | 0.006 | 0.004 | 15.1 | 0.001 |
| Retrolenticular part of internal capsule L (RPIC_L) | 186 | −0.019 | 0.005 | 0.01 | 0.003 | 24.2 | <0.001 |
| Anterior corona radiata R (ACR_R) | 791 | −0.024 | 0.007 | 0.008 | 0.004 | 17.0 | <0.001 |
| Anterior corona radiata L (ACR_L) | 764 | −0.022 | 0.006 | 0.012 | 0.004 | 21.2 | <0.001 |
| Superior corona radiata R (SCR_R) | 678 | −0.016 | 0.006 | 0.012 | 0.004 | 14.5 | 0.001 |
| Superior corona radiata L (SCR_L) | 441 | −0.017 | 0.007 | 0.012 | 0.004 | 15.5 | <0.001 |
| Posterior corona radiata R (PCR_R) | 141 | −0.019 | 0.006 | 0.004 | 0.004 | 9.7 | 0.004 |
| Posterior corona radiata L (PCR_L) | 243 | −0.019 | 0.006 | 0.004 | 0.004 | 11.9 | 0.002 |
| Posterior thalamic radiation R (PTR_R) | 370 | −0.024 | 0.005 | 0.005 | 0.004 | 19.9 | <0.001 |
| Posterior thalamic radiation L (PTR_L) | 182 | −0.024 | 0.006 | 0.007 | 0.004 | 17.2 | <0.001 |
| Sagittal stratum (SS_R) | 121 | −0.028 | 0.006 | 0.003 | 0.004 | 18.3 | <0.001 |
| External capsule R (EC_R) | 235 | −0.021 | 0.004 | 0.006 | 0.004 | 18.0 | <0.001 |
| Cingulum (cingulate gyrus) R (Cingulum_R) | 87 | −0.018 | 0.006 | 0.012 | 0.003 | 22.9 | <0.001 |
| Cingulum (cingulate gyrus) L (Cingulum_L) | 43 | −0.026 | 0.012 | 0.003 | 0.004 | 6.6 | 0.015 |
| Fornix (cres) / Stria terminalis L (Fornix_cres_R) | 78 | −0.024 | 0.005 | 0.006 | 0.005 | 15.4 | <0.001 |
| Fornix (cres) / Stria terminalis L (Fornix_cres_L) | 64 | −0.019 | 0.007 | 0.007 | 0.004 | 9.5 | 0.004 |
| Superior longitudinal fasciculus R (SLF_R) | 827 | −0.027 | 0.006 | 0.008 | 0.004 | 21.1 | <0.001 |
| Superior longitudinal fasciculus L (SLF_L) | 854 | −0.022 | 0.006 | 0.009 | 0.003 | 22.3 | <0.001 |
| Uncinate fasciculus R (UF_R) | 3 | −0.015 | 0.013 | 0.016 | 0.006 | 5.4 | 0.027 |
| Tapetum R (Tapetum_R) | 37 | −0.014 | 0.009 | 0.008 | 0.005 | 4.9 | 0.034 |
Abbreviations: BD: bipolar disorder; TDC: typically developing controls; FDR: false discovery rate