Figure 1.

Anticancer therapy using a site-specific co-delivery strategy. SiRNA and phytochemicals can be coloaded on nanoparticles for promoting their efficacy in cancer therapy. Encapsulation of siRNA in nanoparticles protects against degradation. Nanoparticles enhance bioavailability of natural products. Blood circulation time of siRNA and phytochemicals increases by nanoparticles. Various nanoparticles, such as micelles, liposomes, dendrimers, and polymeric nanoparticles can provide targeted delivery of siRNA and phytochemicals at tumor site, leading to an increase in their efficacy in apoptosis induction.