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Targeting molecular pathways in anticancer therapy using paclitaxel–siRNA-loaded nanoparticles. SiRNA–Beclin inhibits autophagy and enhances the antitumor activity of paclitaxel. SiRNA–STMN1, VEGF, Bcl-2, FAK, survivin, and NF-κB sensitize cancer cells to paclitaxel chemotherapy. The potential of siRNA and paclitaxel in anticancer therapy is boosted when they are loaded into nanoparticles.
