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Down-stream targets of etoposide–siRNA nanoparticles in anticancer therapy. Promotion of etoposide accumulation by nanoparticles and down-regulation of ABCB1 by siRNA. This demonstrates how a combination of nanoparticles and siRNA promotes internalization of etoposide into cancerous cells. Metastasis, angiogenesis, and proliferation are suppressed following co-delivery of siRNA and etoposide by nanoparticles.
