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. 2020 Oct 23;22(12):669–700. doi: 10.1021/acscombsci.0c00099

Table 1. siRNA-Loaded Nanoparticles in Anticancer Therapy.

nanovehicle cancer type cell line target gene size (nm) zeta potential (mV) encapsulation efficiency (EE) (%) drug results ref
polymeric nanoparticles pancreatic cancer HEK293T cell line GRP78 92 +15.14 27–31   high efficiency in silencing GRP78 gene (83.9% decrease in expression) and cytotoxicity against cancer cells (112)
lipid/polymer hybrid nanoassembles prostate cancer PC3 cells EGFR 120.2 –8.8 98   reducing growth and volume of cancer without making toxicity against normal cells (113)
lipid nanoparticle ovarian cancer human ovarian cancer SK-OV-3 cells RPN2 66.5 –9.1 more than 80   effective gene silencing, and excellent cellular uptake (114)
multifunctional nanoplatform lung cancer human lung adenocarcinoma A549 cells PLK1 80–102 5–12 78–80   providing endo/lysosomal escape, having a pH-responsive feature to release a drug in the tumor microenvironment, high cellular uptake, and cytotoxicity (113)
redox-responsive nanoparticles liver cancer human hepatic (L02) and hepatoma cells (HepG2) Bcl-2 85   80 camptothecin accumulation and selective targeting of cancer cells, and induction of apoptosis via Bcl-2 down-regulation (115)
silica nanoparticles breast cancer human breast carcinoma cell line MDA-MB-231 PLK1 100–200 –19     effective elimination of cancer cells via down-regulation of PLK1 (116)
magnetic nanoparticles prostate cancer PC3 cell line ADAM10 15.82–79.20 5–31     high cellular uptake and reducing expression of ADAM10, leading to a decrease in cell viability (115)
polymeric nanoparticles liver cancer Huh7 cells survivin 210 –6.7 53   stimulation of apoptosis in cancer cells via down-regulation of surviving and subsequent induction of Bax and caspase-3 (117)
selenium nanoparticles cervical cancer HeLa human cervical cancer cell derlin-1 less than 150 14.7     enhancing generation of ROS, stimulation of mitochondrial dysfunction and induction of apoptotic cell death (118)
magnetic nanoparticles oral cancer human oral cancer cell Ca9–22 and CAL 27 Bcl-2 26.12 46.5     decreasing viability and survival of cancer cells via down-regulation of Bcl-2 (119)
pH-responsive micelles liver cancer human liver cancer cells SK-Hep1 IL-8 83       high biocompatibility, excellent cellular uptake and effective decrease in gene expression (120)