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. 2020 Oct 23;22(12):669–700. doi: 10.1021/acscombsci.0c00099

Table 3. Curcumin–siRNA Co-delivery in Anticancer Therapy.

nanovehicle cancer type cell line target gene size (nm) zeta potential (mV) encapsulation efficiency (EE) (%) remarks refs
PAMAM dendrimer liver cancer HeLa cells Bcl-2 180 –48 82 high cellular uptake, synergistic impact, down-regulation of Bcl-2 and stimulation of apoptosis (211)
cationic liposome skin cancer mouse melanoma cells (B16F10) STAT3 276.9 42.8 86.8 down-regulation of STAT3 and effective inhibition of tumor growth and viability (216)
cationic liposome skin cancer human epidermoid carcinoma cells (A431) STAT3 195 58.8 87.5 significant reduction in STAT3 expression, resulting in inhibition of cancer growth and invasion (217)
Zn nanoparticle bladder cancer human bladder cancer cell line elF5A2 80–500 +22.3   effective knock-down of elF5A2, induction and apoptosis and reducing proliferation and growth of cancer cells (222)