Scheme 5. Syntheses of AR Ligand-Based PROTACs 21–27.
Reagents and conditions: (a) tert-butyl bromoacetate, K2CO3, ACN, rt; (b) 4.0N HCl in dioxane, rt; (c) HATU, DIPEA, dry DMF, rt; (d) PPh3, DIAD, dry THF, 0 °C-rt; (e) DIPEA, dry DMF, 70 °C.
Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.